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Bujnicki Lab Homepage

HRR in Escherichia coli strain K-12 substr. MG1655

homologous recombination repair

(also known as homologous repair)

Proteins:
PolI
RecA
RecB
RecC
RecD
RecF
RecG
RecJ
RecO
RecR
RuvA
RuvB
RuvC
Enzymatic
complexes:
DNA polymerase III

HRR in KEGG: ecg03440
[picture] [information]



Homologous recombination is a major DNA repair process in bacteria. It is also important for producing genetic diversity in bacterial populations, although the process differs substantially from meiotic recombination, which brings about diversity in eukaryotic genomes. Homologous recombination has been most studied and is best understood for Escherichia coli. Double-strand DNA breaks in bacteria are repaired by the RecBCD pathway of homologous recombination. Breaks that occur on only one of DNA's two strands, known as single-strand gaps, are repaired by the RecF pathway. Both the RecBCD and RecF pathways end with a series of reactions known as branch migration and resolution, carried out by the RuvABC protein complex.

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