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Bujnicki Lab Homepage

BER in Saccharomyces cerevisiae

base excision repair

Proteins:
Apn1p
Apn2p
Cdc9p
Dpb2p
Dpb3p
Hnt3p
Mag1p
Ntg1p
Ntg2p
Ogg1p
Pol delta
Pol epsilon
Pol30p
Pol3p
Rad27p
Ung1p

BER in KEGG: sce03410
[picture] [information]

BER in REACTOME: 1169896



Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.

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