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Bujnicki Lab Homepage

NER in Saccharomyces cerevisiae

nucleotide excision repair

Proteins:
Ccl1p
Cdc9p
Dpb2p
Dpb3p
Kin28p
Met18p
Pol delta
Pol epsilon
Pol30p
Pol3p
Rad10p
Rad14p
Rad1p
Rad23p
Rad26p
Rad28p
Rad2p
Rad3p
Rad4p
Rfc5p
Rpa1p
Ssl2p
Enzymatic
complexes:
RNA POLYMERASE II
Transcription factor II H

NER in KEGG: sce03420
[picture] [information]

NER in REACTOME: 1169810



Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.

Keywords:

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